Any not crit hit by the enemy 'hard-hitter' heads dealt 12+ damage, I can't heal that much damage fast and kill the flesh at the same time, my characters never dodged and the flesh sometimes did! Characters were almost all lvl 4, fully upgraded (for 3 or 4) every run. My characters were almost at full health at the beginning, at turn 4: two were dead, one at death's door, one almost at death's door. Last run today I got 5 crits out of 7 hits from the boss. I am talking about the Orange quest, the second one, I have been playing this game for a couple of months more or less, bought it already with corpses and heart attacks (leave both on), almost 50 hours, so I know a few things, but I just can't seem to win this, I lost so many characters. But for God's sake, the Unstable Flesh makes me cry. I have played difficult games, I have played Dark Souls, I have played Rayman Origins (yes, it's hard, harder than Dark Souls to be honest), I love hard games. I love/hate this game, it's unfair to the point that it's bad game design but there are so many things that I love.

Darkest dungeon flesh guide